The gallery is located in the heart of the Arts District in Old Town Scottsdale, one block south of Indian School Rd., and one block west of Scottsdale Rd.

The Signature Gallery was originally founded in 1997 in Scottsdale, Arizona as the Charles H. Pabst Gallery. With the success of the Scottsdale location, The Signature Gallery Laguna was opened January 1, 2008 to better serve the needs of art collectors and visitors of Southern California. In October of 2009, The Signature Gallery Santa Fe was opened in the historic El Centro Mall. The galleries' goal is to offer high quality art that is highly collectible and will appreciate in value, providing an investment that can be enjoyed for generations.